H₂ inhibitors and/or antagonists act by competing with histamine for histamine type-2 receptor sites on the parietal cell and therefore blocking histamine-stimulated gastric acid secretion. The two most popular H₂ inhibitors and/or antagonists used in horses are cimetidine, marketed as Tagamet® and ranitidine, marketed as Zantac®. H₂ inhibitors/antagonists can be used with antacids like Nutrient Buffer®, but is likely not needed. Nutrient Buffer®, uses time-release ingredients; it is effective and reliable all by itself. Nutrient Buffer® is a natural prostaglandin analogue (similar to lots of pasture for your horse).
Drugs have many drawbacks, and H₂ blockers have some unique ones. Histamine H₂ blockers do exactly what their name implies, they block the histamine from telling the acid producing cells to do their job. The result is another very effective acid blocking drug. When your horse builds a tolerance after prolonged daily use, you find yourself continually increasing the dosage to achieve the same results.
These side effects are very accurately described in the PDR/Physician’s Desk Reference for humans, as these drugs have been used for humans much longer than for horses.
Other side effects reported are: headaches, abdominal discomfort and pain, agitation, anemia, changes in liver function, constipation, depression, diarrhea, difficulty sleeping, dizziness, hair loss, hallucinations, heart block, hepatitis, inflammation of pancreas, involuntary movements, irregular heartbeat, jaundice, joint pain, muscle pain, nausea and vomiting, rapid heartbeat, rash, reduced white blood cells, reversible mental confusion, severe allergic reactions, sleepiness, slow heartbeat, swollen face and throat and vertigo.
The driving factors that lead to a horse suffering from excessive digestive acidity in the first place are not addressed when solely using these drugs. Re-evaluate your feed program, and water quality, if you are considering use of H₂ blockers, inhibitors or antagonists drugs.
Equine Ulcers & Colic in Horses
Nutrient Buffer® is versatile enough to be used daily for horses in every walk of life. With drugs like H₂ Blockers and Proton Pump Inhibitors (PPIs), the body can build a tolerance and require higher dosages over time, while Nutrient Buffer® works the same all the time, every time - with the added benefit of helping resolve colic situations when you need it the most.
Since Marion Dupont-Scott did their classic ulcer study decades ago, showing that race horses tend to dump a lot of stomach acid at the break from the gate, Nutrient Buffer® has been one of the most widely used digestive aid buffering supplements for horses prior to stressful conditions. According to many prominent race track veterinarians, it helps horses race better.
Whether your horse is injured or ill and in recovery, ulcers are known to become a problem in stalled and confined horses. Horses are grazers and designed for continuous movement to aid their digestion and well being.
Nutrient Buffer® has been demonstrated to aid horses with anemia by reducing the binding of iron to lactoferrin and releasing it into the blood and tissues.
A gastric ulcer is essentially a sore on the wall of the stomach, duodenum or even hind gut/large intestine. It is caused by excessive acid secretion by the stomach when there is either no food in the stomach to absorb the acid, or a stimulated excess secretion of acid due to stressful conditions that the horse is under.
Excess acidity and diet problems can provoke a colic attack. Race track veterinarians both use and recommend Nutrient Buffer® as a first approach in colic cases, often eliminating the need for costly surgery. It is the "original" natural digestive aid buffering supplement that helps soothe the gut, and aid in relaxation so the impaction can pass.
The original U.S. patented liquid digestive supplement. 100% USP grade ingredients, drug-free, with over 20 years of success and reliability.